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Fig. 3 | EJNMMI Research

Fig. 3

From: Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Fig. 3

Changes in [18F]-FDG uptake and monocytes fraction in the blood after MERS-CoV aerosol challenge. a K i in mediastinal LNs (y-axis on the left) and monocyte fraction in the blood (y-axis on the right) at different days prior to and after MERS-CoV exposure. b K i in bone marrow and axillary LNs at different days prior to and after MERS-CoV exposure. Each column represents mean ± SD (n = 4). Post hoc analysis by Bonferroni’s multiple comparison test specified a statistically significant increase in K i in mediastinal LNs up to days +15 or +16 post-exposure compared with the K i values prior to virus challenge (adjusted p = 0.0152 on day +3 or +4, p < 0.0001 on days +5 or +6, +7 or +8, and +9 or +10, respectively, and p = 0.0004 on day +15 or +16). c, d Pearson product moment correlation between elevation in [18F]-FDG uptake in mediastinal (c) and axillary (d) LNs and changes in blood monocyte fraction. Abbreviations: FDG, fluorodeoxyglucose; K i , [18F]-FDG uptake rate constant; LNs, lymph nodes

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