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Fig. 5 | EJNMMI Research

Fig. 5

From: Hybrid PET/optical imaging of integrin αVβ3 receptor expression using a 64Cu-labeled streptavidin/biotin-based dimeric RGD peptide

Fig. 5

a MicroPET images of the 64Cu-DOTA-(AF)SAv/biotin-PEG-RGD2 in U87MG tumor-bearing mice at 1, 2, 16, and 21 h after injection and (b) after co-injection with RGD2 (20 mg/kg). c Optical images at the same time points and (d) after co-injection with RGD2 (20 mg/kg). Arrows indicate tumors. e ROI analysis of radioactivity uptake in tumors obtained from microPET images (a, b): control (black) and blocking (white) groups. f ROI analysis of fluorescence intensity in tumors obtained from optical images (c, d): control (black) and blocking (white) groups. Values represent mean % ID/g and error bars indicate SD (n = 3). **P < 0.01, ***P < 0.001

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