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Table 4 Peroxisomal proliferator-activated receptor (PPAR)-related upstream regulators in thyroids exposed to 131I or 211At according to IPA upstream regulator analysis

From: Gene expression signature in mouse thyroid tissue after 131I and 211At exposure

Radionuclide 211At 131I
Time (h) 1 6 24 168 24
Injected activity (kBq) 1.7 100 1.7 7.5 0.064 0.64 1.7 14 42 1.7 13 130 260
Absorbed dose (Gy) 0.023 1.4 0.32 1.4 0.05 0.5 1.4 11 32 1.8 0.85 8.5 17
Gene z score
 Pirinixic acid 3.7 4.7 −0.4 −0.4 5.1 3.6 0.8 −1.4 n.s. 3.5 0.9 1.5 0.2
 PPARA 2.7 3.9 −0.6 −1.5 5.1 3.7 2.0 −0.9 1.4 2.8 −0.9 −0.1 −0.7
 Troglitazone 2.7 5.0 1.6 −0.3 2.9 2.8 1.1 −2.6 −2.2 1.6 −0.1 −1.2 −2.0
 Mono-(2-ethylhexyl)phthalate 2.9 5.6 0.6 0.5 5.0 3.1 1.6 n.s. n.s. 2.4 0.9 1.6 0.0
 PPARG 2.0 5.2 −0.2 −0.9 4.9 2.3 1.8 −1.1 −0.1 2.6 −0.6 1.3 0.0
 PPARGC1A 2.2 4.1 −0.4 1.2 4.5 3.0 0.9 0.8 0.8 2.3 0.0 1.8 0.0
 Rosiglitazone 1.0 5.1 −0.7 −2.1 4.6 1.2 1.8 −0.9 −0.2 2.0 1.2 0.7 0.0
 PPARD 3.1 3.9 1.5 n.s. 3.5 3.7 n.s. −1.3 n.s. 2.6 −0.8 0.3 n.s.
 GW501516 2.6 2.8 0.8 0.8 3.1 3.0 0.0 0.0 0.0 1.8 −1.2 −0.3 0.0
  1. A z score equal to or larger or less than 2 or −2 indicate activated or inhibited upstream regulator, respectively. A z score value between -2 and 2 is considered not statistically significant. n.s. indicates that IPA was not able to predict upstream regulation of that specific upstream regulator for the specific exposure condition