Skip to main content


Fig. 5 | EJNMMI Research

Fig. 5

From: Longitudinal tumor hypoxia imaging with [18F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity

Fig. 5

a Longitudinal relative changes in tumor FAZA uptake with respect to pre-treatment values (%ID/g on day 0). Median values are plotted with the interquartile range indicated by bars. Green asterisk and red asterisk indicate statistically significant difference with respect to the 50 mg/kg irinotecan group and the 5 mg/kg nal-IRI group (p < 0.05), respectively. b Three-dimensional scatterplot of individual tumors at each treatment day with regard to % change in FAZA uptake from baseline (day 0) and % tumor volume change from day 0. For each treatment group, contour ellipsoids (ellipsoid coverage of data points = 70 %) are presented. Tumors are treated with 10 mg/kg nal-IRI (blue ellipsoid), 5 mg/kg nal-IRI (red ellipsoid), and 50 mg/kg irinotecan (gray ellipsoid)

Back to article page