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Fig. 3 | EJNMMI Research

Fig. 3

From: Evaluation of immune cell markers in tumor tissue treated with radioimmunotherapy in an immunocompetent rat colon carcinoma model

Fig. 3

Images of immunohistochemical sections after staining of macrophage markers. CD68 (macrophages, neutrophils, DC, myeloid progenitors, e.g., myeloid suppressor cell) and CD163 (M2, macrophages of pro-tumor type [26, 27]) in sequential sections of paraffin-embedded tumors. The brown staining illustrates the immune cell markers and the blue staining illustrates the cell nuclei. All images show both granulation tissue (filled arrowhead) and tumor cell area (arrowhead). left: untreated tumors, right: tumor 3 days after administration of radioimmunoconjugate. Note the higher number of positive cells for CD68 during this interval than that of CD163. Scale bars: 100 μm

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