Fig. 9
PET imaging of orthotopic brain tumors with [124I]-I2-PARPi. a PET/CT coronal images (left) and corresponding PET images (right) of orthotopic U251 MG brain tumor mice injected with [124I]-I2-PARPi. b PET/CT coronal images (left) and corresponding PET images (right) of a healthy mouse treated with [124I]-I2-PARPi. c Biodistribution of [131I]-I2-PARPi in a U251 MG xenograft mouse model (mice were sacrificed 2 h after tracer injection, additional biodistribution data can be found in Additional file 1: Tables S3A and S3B). d Selected tumor to non-target tissues ratios of [131I]-I2-PARPi. Radioactivity in tissues is expressed as %ID/g