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Fig. 4 | EJNMMI Research

Fig. 4

From: Development of a clickable bimodal fluorescent/PET probe for in vivo imaging

Fig. 4

In vitro uptake and inhibition studies of BODIPY-BBN 5 using GRP receptor overexpressing PC-3 cells. a Confocal microscopy imaging experiment demonstrated cell surface binding of the green fluorescent imaging agent in the green channel (BODIPY, top row); Nuclei were counterstained with Hoechst dye (blue, top row); Blocking studies of BODIPY-BBN 5 were performed with a 100-fold excess of unlabeled GRP receptor antagonist [D-Phe6]-BN(6–13)-ethylester (bottom row). b IC50 values of 5 were evaluated by a competitive binding assay using [125I-Tyr4]-bombesin

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