Fig. 1
From: Development of a clickable bimodal fluorescent/PET probe for in vivo imaging
Conceptual design of the synthesis and application of a bimodal click chemistry tool. After azeotropic distillation of [18 F]-F− n.c.a., the radionuclide was reacted with the BF2 group of an azide-modified BODIPY-FL dye, yielding a 18 F-labeled, bimodal imaging agent. A modular Cu-click protocol allowed the rapid conjugation of the azide dye to targeted peptides, quickly yielding a variety of compounds with only little synthetic effort