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Fig. 1 | EJNMMI Research

Fig. 1

From: Development of a clickable bimodal fluorescent/PET probe for in vivo imaging

Fig. 1

Conceptual design of the synthesis and application of a bimodal click chemistry tool. After azeotropic distillation of [18 F]-F n.c.a., the radionuclide was reacted with the BF2 group of an azide-modified BODIPY-FL dye, yielding a 18 F-labeled, bimodal imaging agent. A modular Cu-click protocol allowed the rapid conjugation of the azide dye to targeted peptides, quickly yielding a variety of compounds with only little synthetic effort

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