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EJNMMI Research

Table 2 Synthetic and analytical data for [18F]AMC13 and [18F]AMC15 homologues

From: Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

Compound

Isolated radiochemical yield, %

Radiochemical purity, %

End-of-synthesis specific activity, GBq/μmol

logD

[18F]FEt-AMC13

12 ± 6

>95

102 ± 30

1.67 ± 0.07

[18F]FPr-AMC13

7 ± 6

>95

29 ± 27

1.98 ± 0.08

[18F]FBu-AMC13

8 ± 7

93 ± 2

85 ± 83

2.50 ± 0.06

[18F]FEt-AMC15

5 ± 3

93 ± 2

25 ± 15

1.48 ± 0.002

[18F]FPr-AMC15

3 ± 1

93 ± 5

9 ± 7

2.39 ± 0.001

[18F]FBu-AMC15

6 ± 0.3

93 ± 6

10 ± 3

2.71 ± 0.07

  1. Values are means ± SD of ≥3 determinations from ≥2 independent experiments
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