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Table 2 Synthetic and analytical data for [18F]AMC13 and [18F]AMC15 homologues

From: Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

Compound Isolated radiochemical yield, % Radiochemical purity, % End-of-synthesis specific activity, GBq/μmol logD
[18F]FEt-AMC13 12 ± 6 >95 102 ± 30 1.67 ± 0.07
[18F]FPr-AMC13 7 ± 6 >95 29 ± 27 1.98 ± 0.08
[18F]FBu-AMC13 8 ± 7 93 ± 2 85 ± 83 2.50 ± 0.06
[18F]FEt-AMC15 5 ± 3 93 ± 2 25 ± 15 1.48 ± 0.002
[18F]FPr-AMC15 3 ± 1 93 ± 5 9 ± 7 2.39 ± 0.001
[18F]FBu-AMC15 6 ± 0.3 93 ± 6 10 ± 3 2.71 ± 0.07
  1. Values are means ± SD of ≥3 determinations from ≥2 independent experiments