Fig. 6

Effect of DMTU on infarct volume following tMCAO in mice. Infarct volume of the total, cortex (CTX-1, CTX-2), striatum (STR), hippocampus (HIP), and thalamus (TH) of mice treated with vehicle or DMTU (100 mg/kg, i.p.) 30 min before tMCAO (90 min) followed by 24-h reperfusion. The infarct area in each slice was measured by the following formula: ((area of the contralateral hemisphere − area of non-ischemic ipsilateral hemisphere)/area of the whole contralateral hemisphere) × 100. The infarct volume was determined by summing up the infarct area of the 1–2 sections and is presented as the percentage of the volume of the contralateral hemisphere. Data are expressed as mean ± SD (n = 12–13 for each group). *P < 0.05, **P < 0.01, as compared with saline