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Table 1 Overview on the fully automated, large-scale radiosyntheses of [11C]Me@HAPTHI

From: Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [11C]ME@HAPTHI

[11C]Me@HAPTHI (n = 7)

Mean

SD

Median

Starting activity [11C]CO2

53.4

2.4

53.9

Trapped [11C]CH4

34.6

4.6

32

Trapped [11C]CH3I

29.6

2.4

29

Trapped [11C]CH3OTf in reactor

16.6

5.5

17.2

After quenching

8.8

3.6

8.9

Loss during injection in loop waste

1.0

0.5

0.8

Product [11C]Me@HAPTHI (EOS)

2.2

2.0

1.9

Yield (decay corr. to EOB)

13.7

13.5

15.9

Specific activity [GBq/μmol] (EOS)

43.4

29.7

59.2

  1. Reaction conditions: [11C]MeOTf, NaOH, MEK, 2 mg/mL precursor concentration
  2. EOS end of synthesis, EOB end of bombardment