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Figure 3 | EJNMMI Research

Figure 3

From: Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease

Figure 3

Autoradiography images and fluorescent immunostaining. Autoradiography images of [18F]-7B binding in an AD frontal cortex section following incubation with [18F]-7B (10 nM) alone (A) or in the presence of 7A (2.5 μM) (C). Fluorescent immunostaining of sections (A) and (C) with an anti-Aβ antibody is shown in (B) and (D), respectively. The autoradiography images demonstrate laminar distribution of [18F]-7B binding in cortex (bracket and arrows), which correlates with the distribution of Aβ plaques shown by fluorescent immunostaining, and binding of [18F]-7B is inhibited by excess cold ligand (C). The higher nonspecific binding in the lower left region (A) is due to folding of the tissue section.

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