Interaction plots between the TBR and the lesion volume. Interaction plots of the lesions’ TBR and the lesion volume on relative SUVmax differences between corresponding PSF and non-PSF algorithms (upper row) or TOF and non-TOF algorithms (lower row), respectively. The TBR and the lesion volume were binarized by their respective median value. In general, an increased effect of the TBR on SUVmax differences is observed in smaller lesions. This interaction between TBR and lesion volume is indicated by non-parallel courses of corresponding gray and black dashed lines.