Metabolic liver function measured in vivo by dynamic 18F-FDGal PET/CT without arterial blood sampling

EJNMMI Research

Table 2 Patients with cirrhosis (functional ¹⁸ F-FDGal PET/CT of the liver using image-derived non-invasive input function)

VOI	Without resolution modelling		With resolution modelling
VOI	Correlation between K * and K , r	Relative deviation of K * from K	Correlation between K * and K , r	Relative deviation of K * from K
Aorta-VOI-1	0.911	0.059 ± 0.040	0.924	0.078 ± 0.039
Aorta-VOI-1	(p < 0.01)	(p = 0.16)	(p < 0.01)	(p = 0.07)
Aorta-VOI-2	0.904	0.044 ± 0.041	0.919	0.051 ± 0.037
Aorta-VOI-2	(p < 0.01)	(p = 0.37)	(p < 0.01)	(p = 0.19)
Aorta-VOI-3	0.897	0.162 ± 0.049	0.893	0.210 ± 0.052
Aorta-VOI-3	(p < 0.01)	(p < 0.01)	(p < 0.01)	(p < 0.01)
Aorta-VOI-4	0.874	0.169 ± 0.055	0.878	0.223 ± 0.057
Aorta-VOI-4	(p < 0.01)	(p < 0.01)	(p < 0.01)	(p < 0.01)
Ventricle-VOI	0.872	0.203 ± 0.058	0.895	0.173 ± 0.050
Ventricle-VOI	(p < 0.01)	(p < 0.01)	(p < 0.01)	(p < 0.01)

K* = hepatic systemic clearance of ¹⁸F-FDGal (ml blood/ml liver tissue/min) estimated using image-derived input function; K = hepatic systemic clearance of ¹⁸F-FDGal (ml blood/ml liver tissue/min) estimated using time-activity curve from manual blood sampling from the radial artery; VOI = volume of interest (see Figure 1 for details on each VOI definition). r = Pearson correlation coefficient for correlation between individual pairs of K* and K; p < 0.05 is considered to indicate statistically significant correlation. Relative deviation of K* from K is presented as mean ± SEM; mean deviation with p < 0.05 is considered statistically significantly different from zero.