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Table 2 Patients with cirrhosis (functional 18 F-FDGal PET/CT of the liver using image-derived non-invasive input function)

From: Metabolic liver function measured in vivo by dynamic 18F-FDGal PET/CT without arterial blood sampling

VOI Without resolution modelling With resolution modelling
Correlation between K * and K , r Relative deviation of K * from K Correlation between K * and K , r Relative deviation of K * from K
Aorta-VOI-1 0.911 0.059 ± 0.040 0.924 0.078 ± 0.039
(p < 0.01) (p = 0.16) (p < 0.01) (p = 0.07)
Aorta-VOI-2 0.904 0.044 ± 0.041 0.919 0.051 ± 0.037
(p < 0.01) (p = 0.37) (p < 0.01) (p = 0.19)
Aorta-VOI-3 0.897 0.162 ± 0.049 0.893 0.210 ± 0.052
(p < 0.01) (p < 0.01) (p < 0.01) (p < 0.01)
Aorta-VOI-4 0.874 0.169 ± 0.055 0.878 0.223 ± 0.057
(p < 0.01) (p < 0.01) (p < 0.01) (p < 0.01)
Ventricle-VOI 0.872 0.203 ± 0.058 0.895 0.173 ± 0.050
(p < 0.01) (p < 0.01) (p < 0.01) (p < 0.01)
  1. K* = hepatic systemic clearance of 18F-FDGal (ml blood/ml liver tissue/min) estimated using image-derived input function; K = hepatic systemic clearance of 18F-FDGal (ml blood/ml liver tissue/min) estimated using time-activity curve from manual blood sampling from the radial artery; VOI = volume of interest (see Figure 1 for details on each VOI definition). r = Pearson correlation coefficient for correlation between individual pairs of K* and K; p < 0.05 is considered to indicate statistically significant correlation. Relative deviation of K* from K is presented as mean ± SEM; mean deviation with p < 0.05 is considered statistically significantly different from zero.