# Table 1 Healthy subjects (functional18F-FDGal PET/CT of the liver using image-derived non-invasive input function)

VOI Without resolution modelling With resolution modelling
Correlation between K * and K , r Relative deviation of K * from K Correlation between K * and K , r Relative deviation of K * from K
Aorta-VOI-1 0.878 −0.044 ± 0.039 0.866 0.016 ± 0.061
(p < 0.01) (p = 0.28) (p < 0.01) (p = 0.79)
Aorta-VOI-2 0.914 −0.076 ± 0.033 0.889 −0.047 ± 0.050
(p < 0.01) (p < 0.05) (p < 0.01) (p = 0.37)
Aorta-VOI-3 0.858 0.071 ± 0.061 0.832 0.143 ± 0.091
(p < 0.01) (p = 0.27) (p < 0.01) (p = 0.14)
Aorta-VOI-4 0.882 0.066 ± 0.057 0.848 0.142 ± 0.088
(p < 0.01) (p = 0.26) (p < 0.01) (p = 0.13)
Ventricle-VOI 0.819 0.141 ± 0.088 0.904 0.044 ± 0.046
(p < 0.01) (p = 0.13) (p < 0.01) (p = 0.35)
1. K* = hepatic systemic clearance of 18F-FDGal (ml blood/ml liver tissue/min) estimated using image-derived input function; K = hepatic systemic clearance of 18F-FDGal (ml blood/ml liver tissue/min) estimated using time-activity curve from manual blood sampling from the radial artery; VOI = volume of interest (see Figure 1 for details on each VOI definition). r = Pearson correlation coefficient for correlation between individual pairs of K* and K; p < 0.05 is considered to indicate statistically significant correlation. Relative deviation of K* from K is presented as mean ± SEM; mean deviation with p < 0.05 is considered statistically significantly different from zero.