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Table 4 Tissue exposure (AUC) for the duration of the PET scan

From: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer

Normal brain AUC (min.g/mL) Tumour metastases AUC (min.g/mL)
Sub 1 - BL 319.6318 Sub 4 met - BL 708.198
Sub 1 - D 8 328.7575 Sub 4 met - D 8 623.23
Sub 3 - BL 304.0247 Sub 7 met 1 - BL 518.227
Sub 3 - D 8 301.1074 Sub 7 met 1 - D 8 665.909
Sub 4 - BL 203.6962 Sub 7 met 2 - BL 2,584.31
Sub 4 - D 8 198.8753 Sub 7 met 2 - D 8 2,757.86
Sub 7 - BL 289.1109 Sub 10 met 1 - D 8 2,731.19
Sub 7 - D 8 272.9378 Sub 10 met 2 - D 8 1,577.81
Sub 9 - D 8 233.2629 Sub 10 met 3 - D 8 2,289.3
Sub 10 - D 8 252.7335 Sub 10 met 4 - D 8 1,647.02
  1. AUC, area under the curve concentration; BL, baseline; D, day; met, metastases; min, minutes; PET, positron emission tomography; Sub, subject.