Figure 2From: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancerFully automated and good manufacturing process-compatible synthesis developed to label lapatinib with radiolabelled carbon-11 in the benzylic position. [11C]Lapatinib was prepared in a two-pot four-step synthesis, with intermediate preparation of [11C]-3-fluorobenzyl iodide that was reacted in the last step with the lapatinib precursor. 11C, carbon-11.Back to article page