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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer

Figure 1

Study hypothesis. It was hypothesised that brain penetration in normal brain would increase with therapeutic serum concentrations of lapatinib due to the effect of lapatinib on drug efflux pumps. Higher brain penetration in metastases compared with normal brain was also hypothesised due to the disruption of the BBB in cranial metastases. 11C, carbon-11 radiolabelled; BBB, blood-brain barrier; PET, positron emission tomography.

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