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Table 3 Biodistribution of [ 68 Ga]DOTATATE and [ 68 Ga]HA-DOTATATE in AR42J tumor-bearing nude mice at 60 min p.i.

From: Twins in spirit - episode I: comparative preclinical evaluation of [68Ga]DOTATATE and [68Ga]HA-DOTATATE

 

[ 68 Ga]DOTATATE

[ 68 Ga]HA-DOTATATE

 

Control

Competition

Control

Competition

Blood

0.3 ± 0.06

0.4 ± 0.2

0.7 ± 0.3

2.5 ± 0.6

Heart

0.3 ± 0.04

0.2 ± 0.1

0.5 ± 0.2

1.0 ± 0.2

Lung

8.4 ± 1.4

0.6 ± 0.2

13.2 ± 1.0

2.5 ± 0.4

Liver

0.5 ± 0.1

0.2 ± 0.05

1.0 ± 0.2

1.0 ± 0.3

Intestine

2.7 ± 0.8

0.6 ± 0.2

4.0 ± 0.7

0.8 ± 0.04

Kidney

3.9 ± 0.5

4.1 ± 0.9

5.3 ± 1.0

17.1 ± 8.7

Spleen

0.9 ± 0.1

0.2 ± 0.03

1.9 ± 0.8

0.7 ± 0.2

Muscle

0.3 ± 0.2

0.2 ± 0.1

0.2 ± 0.1

0.6 ± 0.4

Stomach

15.9 ± 3.9

0.7 ± 0.1

21.7 ± 4.5

1.9 ± 0.8

Adrenals

5.1 ± 1.4

0.4 ± 0.1

10.8 ± 3.2

1.0 ± 0.3

Pancreas

26.1 ± 4.9

0.6 ± 0.03

36.6 ± 4.3

1.5 ± 0.5

AR42J tumor

24.1 ± 4.9

2.0 ± 0.1

33.6 ± 10.9

5.6 ± 0.7

  1. For control experiments, animals (n = 5 per group) were injected with tracer only. For competition experiments, 20 μg/mouse of unlabeled TOC were coinjected with the respective radioligand (n = 3 per group). Data are expressed as %ID/g (mean ± SD).