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EJNMMI Research

Table 1 Lipophilicities of [ 68 Ga]DOTATATE and [ 68 Ga]HA-DOTATATE and their respective 177 Lu-labeled analogs

From: Twins in spirit - episode I: comparative preclinical evaluation of [68Ga]DOTATATE and [68Ga]HA-DOTATATE

Peptide

log P O/PBS

[68Ga]DOTATATE

−3.69

[177Lu]DOTATATE

−3.16

[68Ga]HA-DOTATATE

−3.12

[177Lu]HA-DOTATATE

−2.69

  1. Partition coefficients (logP O/PBS) of the radioligands between PBS (pH 7.4) and n-octanol were determined using a shake flask method (n = 6) [13].
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