Figure 5
From: [18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections
Accumulation of [ 18 F]FDG and [ 18 F]FDG-6-P at the catheter infection site. Mice with S. aureus infections (or uninfected control mice) were injected with approximately 10 MBq [18F]FDG (n = 3 infected, n = 3 uninfected) or approximately 10 MBq [18F]FDG-6-P (n = 3 infected, n = 2 uninfected) 1 h prior to nanoScan PET-CT imaging. (a) Representative 3D colour map of catheter regions cropped from whole-body nanoScan PET-CT images. Images are shown with and without CT. (b) SUV values were calculated for S. aureus-infected (black circle) and uninfected mice (black square). Mann-Whitney U tests confirmed that there were no significant differences in SUVs between infected and uninfected mice injected with either [18F]FDG (P = 0.7619) or [18F]FDG-6-P (P = 0.0556). Bars on the graph show median SUVs for each group (n = 3 for [18F]FDG infected and n = 3 for uninfected mice; n = 3 for [18F]FDG-6-P infected mice and n = 2 uninfected mice). (c) The infected (I) to uninfected (UI) ratio (I/UI) for the catheter sites of mice injected with [18F]FDG and [18F]FDG-6-P was calculated by dividing the mean infected catheter SUV by the mean uninfected catheter SUV for each cohort of mice.