Figure 2

NT-R in vitro receptor autoradiography in PanIN. In vitro receptor autoradiography of NT-R in various PanIN, PanIN 1B (A-C), PanIN 2 (D-F), and PanIN 3 (G-I), and in invasive cancer (J-L). (A), (D), (G), (J) Hematoxylin-eosin-stained sections (bars = 0.1 mm), including insert of representative area at high magnification. (B), (E), (H), (K) Autoradiograms showing total binding of ¹²⁵I-[Tyr³]-neurotensin. While the PanIN 1 case (B) is NT-R-negative, PanIN 2 (E), PanIN 3 (H), and invasive cancer (K) are NT-R-positive. (C), (F), (I), (L) Autoradiograms showing non-specific binding of ¹²⁵I-[Tyr³]-neurotensin (in the presence of 100 nM neurotensin).