Figure 7

Various concentrations of GG918 administered and accumulation of ^99m Tc MIBI in cells measured at 30 min after administration. The C _in/C _out at 30 min after the addition of ^99mTc MIBI is shown in the graph. The C _in/C _out of the N-H, 3-H, and 6-H groups was significantly higher than that of the N-0, 3-0, and 6-0 groups. In addition, the C _in/C _out in the N-H, 3-H, and 6-H groups was significantly higher than those in the N-L, 3-L, and 6-L groups. On the other hand, although there was no significant difference in the values between the N-0 group and the N-L group, those of the 3-L and 6-L groups were significantly higher than those of the 3-0 and 6-0 groups.