Visual comparison of the three radiopharmaceuticals within the same group of animals. Each row represents a mean image of four 24-month-old APP/PS1 transgenic animals (first three rows), respectively, three age matched wild-type animals (C57BL6/J, last three rows). In vivo PET images in each row represent percentage of injected dose per cubic centimeter (%ID/cc) averaged over 35 to 45 min post injection, co-registered to a MRI template. From left to right showing axial, sagittal, and coronal views. Red arrow points at higher unspecific uptake of florbetaben compared to FIBT in the brainstem of wild-type animals.