EJNMMI Research

Table 2 Risk of bias as assessed with the Quadas-2 tool

From: The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review

Study	Risk of bias				Applicability concerns
Study	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Chouker, [20]	+	?	?	+	+	+	+
Marek, [22]	?	+	+	−	+	+	+
Pirker, [23]	+	+	+	+	+	+	+
Marshall, [49]	+	+	+	+	+	+	+
Isaias, [48]	?	?	?	−	+	+	+
Perju-Dumbrava, [46]	−	?	?	+	+	+	+
Colloby, [47]	−	?	?	+	+	+	+
Eggers, [50]	−	+	+	−	+	+	+

+Low risk, −High risk, ?Unclear Risk.

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