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Table 2 Risk of bias as assessed with the Quadas-2 tool

From: The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review

Study Risk of bias Applicability concerns
Patient selection Index test Reference standard Flow and timing Patient selection Index test Reference standard
Chouker, [20] + ? ? + + + +
Marek, [22] ? + + + + +
Pirker, [23] + + + + + + +
Marshall, [49] + + + + + + +
Isaias, [48] ? ? ? + + +
Perju-Dumbrava, [46] ? ? + + + +
Colloby, [47] ? ? + + + +
Eggers, [50] + + + + +
  1. +Low risk, −High risk, ?Unclear Risk.