Figure 4From: The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule The results of the rat bladder strip in vitro model. Rat bladder strip mounted in two parallel organ baths and incubated in 125I-BoNT-A (A) showing no inhibition of contraction force induced by electrical field stimulation (EFS) in time and unlabelled BoNT-A (B) showing inhibition of contraction force induced by EFS in time. Both strips are simultaneously stimulated by potassium chloride (KCl; three times), carbachol (CCh; three times), EFS (repetitive) and CCh (three times). The CCh-induced strip contraction before and after incubation is a viability check of the strip during the experiment.Back to article page