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Figure 4 | EJNMMI Research

Figure 4

From: The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

Figure 4

The results of the rat bladder strip in vitro model. Rat bladder strip mounted in two parallel organ baths and incubated in 125I-BoNT-A (A) showing no inhibition of contraction force induced by electrical field stimulation (EFS) in time and unlabelled BoNT-A (B) showing inhibition of contraction force induced by EFS in time. Both strips are simultaneously stimulated by potassium chloride (KCl; three times), carbachol (CCh; three times), EFS (repetitive) and CCh (three times). The CCh-induced strip contraction before and after incubation is a viability check of the strip during the experiment.

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