EJNMMI Research

Table 1 Tissue-specific absorbed doses

From: Transcriptional response in normal mouse tissues after i.v. ²¹¹At administration - response related to absorbed dose, dose rate, and time

	Mean absorbed dose (mGy)
²¹¹ At activity (kBq)	1.7	105	1.7	7.5	1.7
Time point	1 h	1 h	6 h	6 h	7 days
Kidney cortex	0.29	18	2.6	11	7.6
Kidney medulla	0.29	18	2.6	11	7.6
Liver	0.23	14	2.0	8.9	6.3
Lungs	1.9	116	16	72	50
Spleen	0.86	53	5.7	25	14
Thyroid	23	1,400	320	1,400	1,800

Mean absorbed dose (mGy) to mouse tissues at the time of animal killing after intravenous administration of 1.7, 7.5, or 105 kBq ²¹¹At. Calculations are based on the Medical Internal Radiation Dose (MIRD) formalism [24] with biodistribution data reported by Garg et al. [8].

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