Figure 2

Number of significantly regulated transcripts. Comparison of the total number (no.) of significantly upregulated (positive numbers) and downregulated (negative numbers) transcripts in the kidney cortex and medulla, liver, lungs, and spleen. (A) shows responses at various time points after i.v. administration of 1.7 kBq ²¹¹At. (B) shows total transcript regulation at early time points dependent on dose rate, i.e., effects from 1.7 kBq compared to either 105 kBq ²¹¹At after 1 h or to 7.5 kBq ²¹¹At after 6 h.