Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET

EJNMMI Research

Table 2 Test-retest variability and reproducibility of binding potential (BP _ND ) using cerebral cortex as a reference region

Regions	Logan graphical analysis with input function (t* = 10 min,n = 4)					Reference Logan graphical analysis (t* = 10 min,n = 5)
Regions	Test^a	Retest^a	aTRV^b[%]	TRV^b[%]	ICC^c	Test^a	Retest^a	aTRV^b[%]	TRV^b[%]	ICC^c
Putamen	0.46 (11%)	0.49 (9%)	6	−6 ± 5	0.77	0.50 (17%)	0.53 (16%)	5	−5 ± 4	0.94
Anterior putamen	0.50 (15%)	0.52 (6%)	11	−6 ± 11	0.48	0.53 (18%)	0.57 (16%)	11	−7 ± 9	0.80
Posterior putamen	0.42 (15%)	0.45 (13%)	14	−6 ± 15	0.47	0.47 (21%)	0.48 (16%)	11	−2 ± 13	0.80
Caudate head	0.37 (23%)	0.33 (13%)	21	8 ± 26	0.18	0.38 (20%)	0.39 (29%)	19	0 ± 24	0.58
Thalamus	0.33 (8%)	0.31 (34%)	25	9 ± 31	0.38	0.33 (8%)	0.32 (27%)	22	5 ± 28	0.24
Cerebellum	0.23 (20%)	0.23 (14%)	15	−1 ± 22	0.44	0.23 (20%)^d	0.23 (14%)^d	14^d	− 2 ± 22^d	0.47^d

^aData are presented as mean (%COV); ^bTRV = (p_test − p_retest)/(p_test + p_retest) × 2, and aTRV is the absolute value of TRV; ^cICC = (BSMSS − WSMSS)/(BSMSS + WSMSS) where BSMSS is the mean sum of squares between subjects and WSMSS is the mean sum of squares within subjects; ^dValues for the cerebellum were calculated from four subjects.