EJNMMI Research

Table 2 Biodistribution and residence times of [ ¹⁸ F]AFM in Formosan rock monkeys ^a

From: Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [¹⁸ F]AFM in rats and monkeys

	%ID/organ
	Brain	Lungs	Heart	Liver	Spleen	Kidneys	Bone	Red marrow	Bladder
Time (min) post-injection
15	2.24 ± 0.69	19.26 ± 4.98	1.77 ± 0.27	3.94 ± 0.87	0.17 ± 0.05	2.09 ± 0.53	7.53 ± 2.71	3.40 ± 0.51	0.07 ± 0.04
55	1.98 ± 0.43	5.43 ± 1.42	0.79 ± 0.16	3.03 ± 0.46	0.07 ± 0.02	1.26 ± 0.46	11.17 ± 4.35	7.48 ± 1.46	0.62 ± 0.92
95	1.36 ± 0.30	2.73 ± 0.54	0.43 ± 0.07	2.21 ± 0.43	0.04 ± 0.02	0.74 ± 0.33	9.08 ± 4.36	8.03 ± 2.13	0.78 ± 1.04
110	1.18 ± 0.27	2.21 ± 0.39	0.36 ± 0.05	1.98 ± 0.42	0.03 ± 0.01	0.63 ± 0.30	8.70 ± 3.97	7.89 ± 2.20	0.82 ± 1.13
155	0.81 ± 0.20	1.35 ± 0.22	0.22 ± 0.03	1.30 ± 0.48	0.02 ± 0.01	0.41 ± 0.22	7.21 ± 3.23	6.69 ± 2.15	0.67 ± 1.05
170	0.72 ± 0.17	1.18 ± 0.17	0.19 ± 0.02	1.17 ± 0.46	0.02 ± 0.01	0.35 ± 0.20	6.34 ± 3.12	6.34 ± 2.13	0.66 ± 1.10
215	0.44 ± 0.21	0.72 ± 0.29	0.11 ± 0.05	0.79 ± 0.36	0.01 ± 0.01	0.20 ± 0.15	4.47 ± 2.44	5.16 ± 1.49	0.47 ± 0.68
230	0.39 ± 0.19	0.64 ± 0.25	0.10 ± 0.04	0.70 ± 0.34	0.01 ± 0.01	0.17 ± 0.13	4.09 ± 2.42	4.51 ± 1.19	0.42 ± 0.61
Residence time (h)	0.051 ± 0.013	0.153 ± 0.045	0.034 ± 0.011	0.069 ± 0.025	0.035 ± 0.002	0.019 ± 0.002	0.069 ± 0.031^b	0.325 ± 0.080	0.018 ± 0.024^d
Residence time (h)	0.051 ± 0.013	0.153 ± 0.045	0.034 ± 0.011	0.069 ± 0.025	0.035 ± 0.002	0.019 ± 0.002	0.277 ± 0.125^c	0.325 ± 0.080	0.018 ± 0.024^d

^a n = 8, mean ± SD; non-decay-corrected; ^bResidence time for trabecular bone; ^cResidence time for cortical bone; ^dResidence time for subjects 1 to 3, 4 to 5, and 6 to 7 were 0.0418 ± 0.0247, 0.0059 ± 0.0037, and 0.0007 ± 0.0002, respectively.

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