Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [18 F]AFM in rats and monkeys

EJNMMI Research

Table 1 Experimental dosage regimens for toxicity study of AFM tartrate in male and female rats

^aMaximum human dose is 8 μg per 50-kg person, i.e., 0.16 μg/kg; 0.16 × 37 = 5.92 μg/m². Scaling for the rat gives 5.92 μg/m²/6 = 0.987 μg/kg as an equivalent human dosage. 1,000 × 0.987 = 987 μg/kg as the high dosage; ^bFive rats in each group and of each sex were killed on day 3 (2 days following single dosing) and five on day 15 (14 days following single dosing). Five rats in each group and of each sex were killed on day 7 (2 days following 5-day dosing) and five on day 19 (14 days following 5-day dosing). Dosing of the 5-day dosing animals was initiated 4 days prior to dosing of the single-dose animals so that necropsies occurred on the same calendar day for all groups, thus allowing sharing of control clinical pathology and necropsy data between the two dosage regimens.