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Table 2 Biodistribution of BPA-fr and [18F] FBPA in various organs of RGC6 glioma-bearing Fischer 344 rats ( n  = 7)

From: FBPA PET in boron neutron capture therapy for cancer: prediction of 10B concentration in the tumor and normal tissue in a rat xenograft model

 

Accumulation of BPA-fr by ICP-OES (%ID/g)

Accumulation of FBPA by PET based on maximum count (%ID/g)

Accumulation of FBPA by PET based on average count (%ID/g)

Median

Mean ± SD

Median

Mean ± SD

Median

Mean ± SD

Tumor

1.27

1.44 ± 0.44

1.34

1.36 ± 0.31

0.80

0.79 ± 0.18*

Brain

0.40

0.40 ± 0.06

0.41

0.43 ± 0.07

0.26

0.27 ± 0.07*

Lung

0.93

0.79 ± 0.20

0.39

0.38 ± 0.05*

0.23

0.25 ± 0.05*

Liver

0.72

0.78 ± 0.13

0.78

0.78 ± 0.14

0.59

0.61 ± 0.12

Spleen

0.99

1.07 ± 0.24

0.89

0.88 ± 0.10

0.59

0.58 ± 0.08*

Pancreas

2.65

2.73 ± 0.63

2.64

2.42 ± 0.63

1.76

1.63 ± 0.36*

Small intestine

0.86

0.86 ± 0.13

0.48

0.52 ± 0.10*

0.36

0.36 ± 0.08*

Large intestine

0.68

0.69 ± 0.08

0.44

0.46 ± 0.09*

0.30

0.30 ± 0.07

Kidney

4.06

4.34 ± 0.84

5.52

5.70 ± 0.89*

4.56

4.66 ± 0.76

Blood

0.65

0.64 ± 0.05

0.59

0.61 ± 0.14

0.45

0.47 ± 0.10*

  1. *p < 0.05 compared to BPA-fr by ICP-OES.