Table 1 Experimental groups used for adrenergic stress characterization of coronary endothelial function
Adrenergic stress agent | Receptor target | I.V. dose (μg/kg/min) | Cardiovascular effects | Normal mice (n) | NOS-inhibition mice (n) | eNOS-knockout mice (n) |
|---|---|---|---|---|---|---|
NE | Alpha-agonist + beta-agonist | 3.2 | Alpha peripheral vasoconstriction beta1 cardiac inotropy and chronotropy beta2 coronary and bronchial dilatation | 5 | 5 | 5 |
PHE + NE | Alpha-antagonist + beta-agonist | 3.2 | Alpha peripheral vasodilatation beta1 cardiac inotropy and chronotropy beta2 coronary and bronchial dilatation | 5 | ||
SB high-dose | Beta2-agonist | 1.0 | Beta2 coronary and bronchial dilatation | 5 | 5 | |
SB low-dose | Beta2-agonist | 0.2 | Beta2 coronary and bronchial dilatation | 5 | 5 |