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EJNMMI Research
Figure 6 | EJNMMI Research

Figure 6

From: β2-adrenergic stress evaluation of coronary endothelial-dependent vasodilator function in mice using 11C-acetate micro-PET imaging of myocardial blood flow and oxidative metabolism

Figure 6

NOS-inhibition effects on myocardial blood flow index response (MBFi ratio) to adrenergic stress agents. Norepinephrine (NE) 1.6, 3.2, and 5.6 μg/kg/min and salbutamol (SB) low-dose 0.2 μg/kg/min and high-dose 1.0 μg/kg/min. (A) MBFi vs. RPP response (stress/rest), (B) MBFi adjusted to the mean RPP-ratio (MBFiadj ratio), (C) MBFi vs. oxygen metabolism response (stress/rest MVO2 ratio), and (D) adjusted MBFi vs MVO2 ratio. After adjusting for the RPP-effects on MBFi, NOS inhibition results in proportional reductions in the MBFi and MVO2 responses to adrenergic stress (arrows shown in (D)).

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