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Figure 5 | EJNMMI Research

Figure 5

From: An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography

Figure 5

[11C]GSK1034702 in Subject 4 in the human brain. Tracer [11C]GSK1034702 PET data - integral images 0-120 min in subject 4. Post dose 5 mg of GSK1034702 [11C]GSK1034702 PET data - integral images 0-120 min in subject 4. K1 = rate constant for transfer from arterial plasma to tissue (mL.cm−3.min−1). VT = volume of distribution (mL.cm−3). Regions of interest: MTL = medial temporal lobe (ROI defined above), cerebellum, thalamus and striatum and cortex = sum of cortical regions (includes grey and white matter); white matter = all cerebral white matter.

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