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EJNMMI Research

Table 3 Lipophilicity of the radiolabelled ligands (log P(o/w); distribution coefficient in n-octanol/PBS)

From: Synthesis and preclinical evaluation of DOTAGA-conjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer

Ligand

logP(o/w)

[68Ga]HBED-CC-Ahx-KuE

 

-4.1 ± 0.1

[68Ga]DOTA-FFK(Sub-KuE)

(68Ga-10)

-3.1 ± 0.2

[177Lu]DOTA-FFK(Sub-KuE)

(177Lu-10)

2.7 ± 0.02

[68Ga]DOTAGA-FFK/ffk(Sub-KuE)

(68Ga-11/12)a

-3.6 ± 0.1

[177Lu]DOTAGA-FFK/ffk(Sub-KuE)

(177Lu-11/12)a

-3.9 ± 0.1

  1. Data are expressed as mean ± SD (n =6). aDetermined for 68Ga-11 and 177Lu-11.
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