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Table 3 Lipophilicity of the radiolabelled ligands (log P(o/w); distribution coefficient in n-octanol/PBS)

From: Synthesis and preclinical evaluation of DOTAGA-conjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer

Ligand logP(o/w)
[68Ga]HBED-CC-Ahx-KuE   -4.1 ± 0.1
[68Ga]DOTA-FFK(Sub-KuE) (68Ga-10) -3.1 ± 0.2
[177Lu]DOTA-FFK(Sub-KuE) (177Lu-10) 2.7 ± 0.02
[68Ga]DOTAGA-FFK/ffk(Sub-KuE) (68Ga-11/12)a -3.6 ± 0.1
[177Lu]DOTAGA-FFK/ffk(Sub-KuE) (177Lu-11/12)a -3.9 ± 0.1
  1. Data are expressed as mean ± SD (n =6). aDetermined for 68Ga-11 and 177Lu-11.