Scheme 2From: Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-11C]tryptophan isotopologue based on deuterium kinetic isotope effectsTheoretical metabolism of [11C]DHTP in neuroendocrine cells. [11C]DHTP is converted into [11C2H]5-HT by AADC. Deamination by MAO-A, and the subsequent cellular washout in the form of [11C2H]5-HIAA, is theoretically reduced by a secondary KIE.Back to article page