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Table 3 Average bias (%) for all parameters derived from simulated tissue TACs of all three simulated tissues

From: Quantification of [11C]-meta-hydroxyephedrine uptake in human myocardium

  Noise K11T2k VT1T2k K12T3k K i 2T3k K12T4k VT2T4k
Healthy 0% -26.37 -22.01 -19.00 21.51 0.00 0.00
1% -26.54 -21.58 -18.99 21.52 0.01 0.31
5% -26.47 -20.97 -18.43 22.36 0.47 7.41
10% -26.37 -18.03 -15.01 27.49 3.76 14.49
20% -26.17 -10.74 -6.73 39.91 8.23 15.56
Scar 0% -22.07 -11.97 -15.27 41.21 0.00 0.00
1% -22.26 -11.88 -15.26 41.23 0.00 0.20
5% -22.26 -11.78 -15.21 41.32 0.57 14.19
10% -22.32 -10.73 -14.50 42.50 3.12 95.17
20% -21.79 -8.99 -11.65 47.25 14.08 208.98
Denervated 0% -29.56 -12.35 -20.71 58.59 0.00 0.00
1% -29.79 -12.35 -20.68 58.63 0.03 0.02
5% -29.74 -12.19 -20.72 58.56 0.28 1.24
10% -29.68 -12.13 -20.39 59.22 0.38 18.55
20% -29.52 -10.95 -18.95 62.10 4.33 82.07
  1. Bias was calculated by comparing the obtained values of K1, VT and K i with those used in the 2T4k model to generate time-activity curves (i.e. the 2T4k model has no bias for 0% noise). Bias due to noise can be appreciated by comparing the obtained bias with those at 0% noise.