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Table 2 Tumour-to-tissue (T/Ti) ratios of 111 In-DTPA-11B6 in NMRI nude mice carrying LNCaP xenografts

From: Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6

  4 h 24 h 48 h 72 h 168 h
Heart 0.99 ± 0.44 3.0 ± 0.13 6.2 ± 1.5 6.7 ± 1.7 38 ± 58
Lung 0.75 ± 0.43 2.3 ± 0.21 3.5 ± 1.4 3.7 ± 1.4 5.2 ± 1.5
Liver 0.79 ± 0.34 2.2 ± 0.44 3.8 ± 0.96 3.5 ± 1.0 4.4 ± 0.28
Spleen 0.99 ± 0.45 2.5 ± 0.46 3.2 ± 0.27 3.1 ± 0.57 3.7 ± 0.83
GI tract 3.5 ± 1.6 9.8 ± 1.6 17 ± 3.5 14 ± 1.3 30 ± 8.2
Kidneys 0.62 ± 0.25 2.0 ± 0.24 3.9 ± 1.2 4.2 ± 0.71 6.8 ± 1.5
Salivary 2.3 ± 0.98 1.9 ± 0.24 1.8 ± 0.35 1.2 ± 0.32 1.2 ± 0.37
Muscle 10 ± 5 11 ± 5.3 25 ± 21 16 ± 4.8 40 ± 11
Bone 3.5 ± 0.81 7.0 ± 1.4 7 ± 3.9 10 ± 3.6 9.2 ± 2.6
Brain 12 ± 6.6 39 ± 4.5 75 ± 31 74 ± 22 118 ± 13
Prostate 3.7 ± 1.3 3.5 ± 0.99 12 ± 7.0 8.2 ± 3.0 12 ± 1.5
Testes 1.9 ± 0.82 5.0 ± 0.77 11 ± 2.2 9.5 ± 2.4 11 ± 3.9