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Table 2 Tumour-to-tissue (T/Ti) ratios of 111 In-DTPA-11B6 in NMRI nude mice carrying LNCaP xenografts

From: Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6

 

4 h

24 h

48 h

72 h

168 h

Heart

0.99 ± 0.44

3.0 ± 0.13

6.2 ± 1.5

6.7 ± 1.7

38 ± 58

Lung

0.75 ± 0.43

2.3 ± 0.21

3.5 ± 1.4

3.7 ± 1.4

5.2 ± 1.5

Liver

0.79 ± 0.34

2.2 ± 0.44

3.8 ± 0.96

3.5 ± 1.0

4.4 ± 0.28

Spleen

0.99 ± 0.45

2.5 ± 0.46

3.2 ± 0.27

3.1 ± 0.57

3.7 ± 0.83

GI tract

3.5 ± 1.6

9.8 ± 1.6

17 ± 3.5

14 ± 1.3

30 ± 8.2

Kidneys

0.62 ± 0.25

2.0 ± 0.24

3.9 ± 1.2

4.2 ± 0.71

6.8 ± 1.5

Salivary

2.3 ± 0.98

1.9 ± 0.24

1.8 ± 0.35

1.2 ± 0.32

1.2 ± 0.37

Muscle

10 ± 5

11 ± 5.3

25 ± 21

16 ± 4.8

40 ± 11

Bone

3.5 ± 0.81

7.0 ± 1.4

7 ± 3.9

10 ± 3.6

9.2 ± 2.6

Brain

12 ± 6.6

39 ± 4.5

75 ± 31

74 ± 22

118 ± 13

Prostate

3.7 ± 1.3

3.5 ± 0.99

12 ± 7.0

8.2 ± 3.0

12 ± 1.5

Testes

1.9 ± 0.82

5.0 ± 0.77

11 ± 2.2

9.5 ± 2.4

11 ± 3.9