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Table 1 Tissue-to-blood (Ti/B) ratios of 111 In-DTPA-11B6 in NMRI nude mice carrying LNCaP xenografts

From: Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6

  4 h 24 h 48 h 72 h 168 h
Tumour 0.23 ± 0.10 0.80 ± 0.12 1.6 ± 0.41 1.7 ± 0.44 2.4 ± 0.62
Heart 0.23 ± 0.02 0.26 ± 0.03 0.26 ± 0.03 0.24 ± 0.02 0.22 ± 0.16
Lung 0.33 ± 0.12 0.36 ± 0.07 0.48 ± 0.12 0.43 ± 0.07 0.47 ± 0.05
Liver 0.28 ± 0.04 0.36 ± 0.02 0.43 ± 0.03 0.44 ± 0.04 0.55 ± 0.14
Spleen 0.23 ± 0.06 0.34 ± 0.09 0.50 ± 0.09 0.49 ± 0.07 0.64 ± 0.06
GI tract 0.07 ± 0.004 0.08 ± 0.003 0.09 ± 0.01 0.11 ± 0.04 0.08 ± 0.01
Kidneys 0.35 ± 0.05 0.40 ± 0.03 0.41 ± 0.05 0.37 ± 0.04 0.35 ± 0.03
Salivary 0.10 ± 0.01 0.44 ± 0.08 0.86 ± 0.11 1.3 ± 0.11 2.1 ± 0.38
Muscle 0.02 ± 0.003 0.08 ± 0.03 0.09 ± 0.05 0.09 ± 0.02 0.06 ± 0.01
Bone 0.07 ± 0.03 0.12 ± 0.01 0.34 ± 0.34 0.17 ± 0.05 0.27 ± 0.07
Brain 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.001 0.02 ± 0.003
Prostate 0.06 ± 0.01 0.24 ± 0.04 0.14 ± 0.04 0.19 ± 0.04 0.20 ± 0.05
Testes 0.12 ± 0.02 0.16 ± 0.02 0.15 ± 0.02 0.17 ± 0.02 0.27 ± 0.20