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Figure 1 | EJNMMI Research

Figure 1

From: Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6

Figure 1

Biokinetics of111In-DTPA-11B6. (a) Biodistribution of 111In-DTPA-11B6 in NRMI nude mice carrying LNCaP xenografts. %IA/g ± SD, 3 to 5 animals per time point. (b) Biodistribution of 111In-DTPA-11B6 in normal NMRI mice at 48 h. An overall lower %IA/g was observed as compared to tumour-bearing mice but with a retained high uptake in the salivary glands. (c) Left, tumour-to-blood ratio is steadily increasing over the time of the experiment. Right, tumour-to-muscle ratio. This high, increasing ratio explains the good visualization and contrast observed in SPECT/CT images. (See Figure 3)

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