Target | In vitrodata | PET data | ||||||
---|---|---|---|---|---|---|---|---|
Bmax | Kd | Vu,brain | ftb | BPND | ftb | |||
(nM)b | (nM) | (mL/g brain) | ||||||
[18 F]2-FA-85380 | Yes | nAChr a4b2 | 0.7 | 0.145 | 1.7 | 0.74 | 1.8 | 0.64 |
[11C]AFM | Yes | SERT | 38 | 1.04 | 46 | 0.44 | 1.4 | 0.58 |
[18 F]Altanserin | Yes | 5HT2a | 89 | 0.32 | 122 | 0.70 | 1.06 | 0.51 |
[11C]AZ10419369 | Yes | 5HT1b | 9.8c | 0.37 | 30 | 0.47 | 1.3 | 0.57 |
[11C]AZD2184 | Yes | Amyloid | 1,407 | 4.9 | 33 | 0.90 | 1.1 | 0.52 |
[11C]AZD2995 | Yes | Amyloid | 1,407 | 6.2 | 7 | 0.97 | 0.6 | 0.38 |
[18 F]AZD4694 | Yes | Amyloid | 1,407 | 2.3 | 205 | 0.75 | 1.2 | 0.55 |
[11C]CP-126998 | Yes | AchE | 211 | 0.48 | 41 | 0.92 | ||
[11C]DASB | Yes | SERT | 38 | 3.5 | 31 | 0.26 | 1.6 | 0.62 |
[18 F]Fallypridef | Yes | D2 | 27 | 0.03 | 18 | 0.98 | 22.2 | 0.96 |
[18 F]Fallyprideg | Yes | D2 | 0.9 | 0.03 | 18 | 0.63 | 2.11 | 0.68 |
[18 F]FE-PE2I | Yes | DAT | 212 | 12 | 62 | 0.22 | 4.1 | 0.80 |
[18 F]FEPPA[iv] | Yes | TSPO | 58 | 0.07 | 15 | 0.98 | 4.4 | 0.81 |
[11C]FLB457 | Yes | D2 | 0.9 | 0.02 | 26 | 0.63 | 2.6 | 0.72 |
[11C]Flumazenil | Yes | GABA | 71 | 0.7 | 3.2 | 0.97 | 5.8 | 0.85 |
[18 F]FP-CIT | Yes | DAT | 212 | 33 | 36 | 0.15 | 1.0 | 0.50 |
[11C]GR103545 | Yes | KOR | 3.75c | 0.048 | 41 | 0.66 | 2.18 | 0.69 |
[11C]GR205171 | Yes | NK1 | 55 | 0.016 | 57 | 0.98 | 14.5 | 0.94 |
[11C]GSK189254A | Yes | H3 | 8.4 | 0.08 | 8.5 | 0.93 | 1.3 | 0.57 |
[11C]Harmine | Yes | MAO-A | 270 | 5 | 25 | 0.68 | 1.7 | 0.63 |
[11C]MADAM | Yes | SERT | 38 | 0.06 | 90 | 0.88 | 1.4 | 0.58 |
[11C]McN5652 | Yes | SERT | 38 | 0.2 | 238 | 0.44 | 0.50 | 0.33 |
[11C]MDL100907 | Yes | 5HT2a | 89 | 0.24 | 17 | 0.96 | 1.3 | 0.57 |
[11C]MePPEP | Yes | CB1r | 47 | 0.1 | 296 | 0.61 | 5.5 | 0.85 |
[18 F]MPPF | Yes | 5HT1a | 350 | 3.3 | 14 | 0.89 | 1.6 | 0.62 |
[11C]NNC112 | Yes | D1 | 93 | 0.18 | 70 | 0.88 | 2.85 | 0.74 |
[11C]PBR28 | Yes | TSPO | 58 | 1.8 | 11 | 0.75 | 3.99 | 0.80 |
[11C]PE2I | Yes | DAT | 212 | 4.9 | 39 | 0.53 | 8.0 | 0.89 |
[11C]PHNO | Yes | D2/D3 | 26.5d | 0.56 | 11 | 0.81 | 2.5 | 0.71 |
[11C]PIB | Yes | Amyloid | 1,407 | 2.5 | 250 | 0.69 | 0.85 | 0.46 |
[11C]PK11195 | Yes | TSPO | 58 | 4.3 | 59 | 0.19 | 0.18 | 0.15 |
[11C]Raclopride | Yes | D2 | 27 | 2.5 | 9.4 | 0.53 | 2.6 | 0.72 |
[18 F]Spiperone | Yes | D2 | 27 | 0.028 | 147 | 0.87 | ||
[11C]SB207145 | Yes | 5HT4 | 21 | 0.037 | 4.4 | 0.99 | 3.4 | 0.77 |
[11C]SCH23390 | Yes | D1 | 93 | 2.1 | 32 | 0.58 | 1.8 | 0.64 |
[11C]WAY100635 | Yes | 5HT1a | 350 | 1.1 | 14 | 0.96 | 7.4 | 0.88 |
[11C]Citalopram | No | SERT | 38 | 4.8 | 60 | 0.12 | 0.1 | 0.09 |
[11C]Clomipramine | No | SERT | 38 | 0.15 | 863 | 0.23 | 0.1 | 0.09 |
[11C]CPEB[iv] | No | ORL-1 | 13.5e | 1.1 | 143 | 0.08 | 0.1 | 0.09 |
[11C]Desipramine | No | NET | 5 | 0.63 | 264 | 0.03 | 0.1 | 0.09 |
[11C]Diazepam | No | GABA | 71 | 7 | 20 | 0.34 | 0.1 | 0.09 |
[11C]MeNER | No | NET | 5c | 2.5 | 31 | 0.06 | 0.3 | 0.23 |
[11C]NE100 | No | Sigma | 23e | 1.2 | 96 | 0.17 | 0.1 | 0.09 |
[11C]Nisoxetine | No | NET | 5 | 0.73 | 58 | 0.11 | 0.1 | 0.09 |
[18 F]Paroxetine | No | SERT | 38 | 0.065 | 876 | 0.40 | 0.1 | 0.09 |
[11C]Remoxipride | No | D2 | 27 | 270 | 6.3 | 0.02 | 0.1 | 0.09 |
[11C]Sertraline | No | SERT | 38 | 0.15 | 4,184 | 0.06 | 0.1 | 0.09 |
[11C]Venlafaxine | No | SERT | 38 | 7.5 | 10 | 0.33 | 0.1 | 0.09 |