| |
Target
|
In vitrodata
|
PET data
|
---|
|
Bmax
|
Kd
|
Vu,brain
|
ftb
|
BPND
|
ftb
|
---|
|
(nM)b
|
(nM)
|
(mL/g brain)
| | | |
---|
[18 F]2-FA-85380
|
Yes
|
nAChr a4b2
|
0.7
|
0.145
|
1.7
|
0.74
|
1.8
|
0.64
|
[11C]AFM
|
Yes
|
SERT
|
38
|
1.04
|
46
|
0.44
|
1.4
|
0.58
|
[18 F]Altanserin
|
Yes
|
5HT2a
|
89
|
0.32
|
122
|
0.70
|
1.06
|
0.51
|
[11C]AZ10419369
|
Yes
|
5HT1b
|
9.8c
|
0.37
|
30
|
0.47
|
1.3
|
0.57
|
[11C]AZD2184
|
Yes
|
Amyloid
|
1,407
|
4.9
|
33
|
0.90
|
1.1
|
0.52
|
[11C]AZD2995
|
Yes
|
Amyloid
|
1,407
|
6.2
|
7
|
0.97
|
0.6
|
0.38
|
[18 F]AZD4694
|
Yes
|
Amyloid
|
1,407
|
2.3
|
205
|
0.75
|
1.2
|
0.55
|
[11C]CP-126998
|
Yes
|
AchE
|
211
|
0.48
|
41
|
0.92
| | |
[11C]DASB
|
Yes
|
SERT
|
38
|
3.5
|
31
|
0.26
|
1.6
|
0.62
|
[18 F]Fallypridef
|
Yes
|
D2
|
27
|
0.03
|
18
|
0.98
|
22.2
|
0.96
|
[18 F]Fallyprideg
|
Yes
|
D2
|
0.9
|
0.03
|
18
|
0.63
|
2.11
|
0.68
|
[18 F]FE-PE2I
|
Yes
|
DAT
|
212
|
12
|
62
|
0.22
|
4.1
|
0.80
|
[18 F]FEPPA[iv]
|
Yes
|
TSPO
|
58
|
0.07
|
15
|
0.98
|
4.4
|
0.81
|
[11C]FLB457
|
Yes
|
D2
|
0.9
|
0.02
|
26
|
0.63
|
2.6
|
0.72
|
[11C]Flumazenil
|
Yes
|
GABA
|
71
|
0.7
|
3.2
|
0.97
|
5.8
|
0.85
|
[18 F]FP-CIT
|
Yes
|
DAT
|
212
|
33
|
36
|
0.15
|
1.0
|
0.50
|
[11C]GR103545
|
Yes
|
KOR
|
3.75c
|
0.048
|
41
|
0.66
|
2.18
|
0.69
|
[11C]GR205171
|
Yes
|
NK1
|
55
|
0.016
|
57
|
0.98
|
14.5
|
0.94
|
[11C]GSK189254A
|
Yes
|
H3
|
8.4
|
0.08
|
8.5
|
0.93
|
1.3
|
0.57
|
[11C]Harmine
|
Yes
|
MAO-A
|
270
|
5
|
25
|
0.68
|
1.7
|
0.63
|
[11C]MADAM
|
Yes
|
SERT
|
38
|
0.06
|
90
|
0.88
|
1.4
|
0.58
|
[11C]McN5652
|
Yes
|
SERT
|
38
|
0.2
|
238
|
0.44
|
0.50
|
0.33
|
[11C]MDL100907
|
Yes
|
5HT2a
|
89
|
0.24
|
17
|
0.96
|
1.3
|
0.57
|
[11C]MePPEP
|
Yes
|
CB1r
|
47
|
0.1
|
296
|
0.61
|
5.5
|
0.85
|
[18 F]MPPF
|
Yes
|
5HT1a
|
350
|
3.3
|
14
|
0.89
|
1.6
|
0.62
|
[11C]NNC112
|
Yes
|
D1
|
93
|
0.18
|
70
|
0.88
|
2.85
|
0.74
|
[11C]PBR28
|
Yes
|
TSPO
|
58
|
1.8
|
11
|
0.75
|
3.99
|
0.80
|
[11C]PE2I
|
Yes
|
DAT
|
212
|
4.9
|
39
|
0.53
|
8.0
|
0.89
|
[11C]PHNO
|
Yes
|
D2/D3
|
26.5d
|
0.56
|
11
|
0.81
|
2.5
|
0.71
|
[11C]PIB
|
Yes
|
Amyloid
|
1,407
|
2.5
|
250
|
0.69
|
0.85
|
0.46
|
[11C]PK11195
|
Yes
|
TSPO
|
58
|
4.3
|
59
|
0.19
|
0.18
|
0.15
|
[11C]Raclopride
|
Yes
|
D2
|
27
|
2.5
|
9.4
|
0.53
|
2.6
|
0.72
|
[18 F]Spiperone
|
Yes
|
D2
|
27
|
0.028
|
147
|
0.87
| | |
[11C]SB207145
|
Yes
|
5HT4
|
21
|
0.037
|
4.4
|
0.99
|
3.4
|
0.77
|
[11C]SCH23390
|
Yes
|
D1
|
93
|
2.1
|
32
|
0.58
|
1.8
|
0.64
|
[11C]WAY100635
|
Yes
|
5HT1a
|
350
|
1.1
|
14
|
0.96
|
7.4
|
0.88
|
[11C]Citalopram
|
No
|
SERT
|
38
|
4.8
|
60
|
0.12
|
0.1
|
0.09
|
[11C]Clomipramine
|
No
|
SERT
|
38
|
0.15
|
863
|
0.23
|
0.1
|
0.09
|
[11C]CPEB[iv]
|
No
|
ORL-1
|
13.5e
|
1.1
|
143
|
0.08
|
0.1
|
0.09
|
[11C]Desipramine
|
No
|
NET
|
5
|
0.63
|
264
|
0.03
|
0.1
|
0.09
|
[11C]Diazepam
|
No
|
GABA
|
71
|
7
|
20
|
0.34
|
0.1
|
0.09
|
[11C]MeNER
|
No
|
NET
|
5c
|
2.5
|
31
|
0.06
|
0.3
|
0.23
|
[11C]NE100
|
No
|
Sigma
|
23e
|
1.2
|
96
|
0.17
|
0.1
|
0.09
|
[11C]Nisoxetine
|
No
|
NET
|
5
|
0.73
|
58
|
0.11
|
0.1
|
0.09
|
[18 F]Paroxetine
|
No
|
SERT
|
38
|
0.065
|
876
|
0.40
|
0.1
|
0.09
|
[11C]Remoxipride
|
No
|
D2
|
27
|
270
|
6.3
|
0.02
|
0.1
|
0.09
|
[11C]Sertraline
|
No
|
SERT
|
38
|
0.15
|
4,184
|
0.06
|
0.1
|
0.09
|
[11C]Venlafaxine
|
No
|
SERT
|
38
|
7.5
|
10
|
0.33
|
0.1
|
0.09
|
- aAn extended version of this table is provided as supporting information (Additional file 1: Table S1), which includes literature references to Bmax, Kd, and BPND for each tracer, details of Vu,brain determination, calculated molecular descriptors and CNS PET MPO score, and the region of brain tissue interest.
- bData refers to human brain tissue unless otherwise specified.
- cMonkey.
- dDog.
- eRat.
- fBmax value refers to caudate.
- gBmax value refers to thalamus.