Figure 5From: Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brainLack of close correlation between ACDlogD7.4 and V u,brain for the functioning ( blue ) and non-functioning ( red ) PET tracers. Dashed lines represent commonly applied PET-ligand selection criteria; vertical lines border the desired range of lipophilicity, and the horizontal line indicates the maximum level of non-specific binding.Back to article page