Skip to main content

Table 6 Activities and peptide mass needed for an absorbed dose of 60 Gy in a 300-mg tumour

From: Therapeutic application of CCK2R-targeting PP-F11: influence of particle range, activity and peptide amount

  90Y - PP-F11 111In - PP-F11 177Lu - PP-F11 213Bi - PP-F11
N × activity (MBq) 1 × 111 4 × 20 8 × 174 6 × 47 10 × 19
N × peptide (nmol) 0.28 4 × 0.05 8 × 0.21 6 × 0.39 10 × 0.47
Relative uptake (%) 70 97 75 62 57
Tumour mass (mg) Mean absorbed dose to tumour (Gy)
1 11 47 45 55
5 19 52 52 57
10 23 54 54 58
50 38 56 58 59
100 46 57 59 59
200 55 59 60 60
300 60 60 60 60
500 68 61 38 60
  1. Multiple (N) injections were considered; only 90Y could attain 60 Gy by a single injection. The relative uptake reduction factor by the higher peptide mass is indicated. The mean absorbed doses are given for tumour spheres varying in mass between 1 and 500 mg according to the mentioned activity and assuming the double-exponential clearance with T1/2 = 2.7 h (60%) and 150 h (40%) without tumour growth. The absorbed dose for 213Bi was not corrected for its relative effectiveness (RBE = 1).