EJNMMI Research

Table 6 Activities and peptide mass needed for an absorbed dose of 60 Gy in a 300-mg tumour

From: Therapeutic application of CCK2R-targeting PP-F11: influence of particle range, activity and peptide amount

	⁹⁰Y - PP-F11		¹¹¹In - PP-F11	¹⁷⁷Lu - PP-F11	²¹³Bi - PP-F11
N × activity (MBq)	1 × 111	4 × 20	8 × 174	6 × 47	10 × 19
N × peptide (nmol)	0.28	4 × 0.05	8 × 0.21	6 × 0.39	10 × 0.47
Relative uptake (%)	70	97	75	62	57
Tumour mass (mg)	Mean absorbed dose to tumour (Gy)
1	11		47	45	55
5	19		52	52	57
10	23		54	54	58
50	38		56	58	59
100	46		57	59	59
200	55		59	60	60
300	60		60	60	60
500	68		61	38	60

Multiple (N) injections were considered; only ⁹⁰Y could attain 60 Gy by a single injection. The relative uptake reduction factor by the higher peptide mass is indicated. The mean absorbed doses are given for tumour spheres varying in mass between 1 and 500 mg according to the mentioned activity and assuming the double-exponential clearance with T_1/2 = 2.7 h (60%) and 150 h (40%) without tumour growth. The absorbed dose for ²¹³Bi was not corrected for its relative effectiveness (RBE = 1).

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