Figure 1

Biodistribution and kinetic profile. (A) Biodistribution of 0.03 nmol ¹¹¹In-labelled PP-F11 in nude mice with CCK2R-transfected A431 tumour xenografts at 1 and at 4 h (reproduced from [1]). (B) Kinetic profile of radioactivity uptake in the CCK2 receptor-positive tumour xenograft with three options that are considered for the uptake phase: single-exponential, fast uptake with T_1/2 of 2.7 min and slow uptake with T_1/2 of 17 min. (C) Variance in kinetic profile of the radioactivity clearance from the tumour: the solid blue curve shows the single exponential with T_1/2 of 4.9 h, the middle dashed red curve shows the double exponential with final clearance T_1/2 of 150 h and the blue dotted curves show the 95% confidence interval for the tumour clearance.