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Table 2 Effect of GSH concentration on the amplitudes of fast and slow clearance rates of 64 Cu(ATSM)

From: Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM)

Amplitude of clearance rate Type of heart Injection Untreated BSO NAC
FCR Normoxic hearts Normoxia 0.7 ± 0.02 0.8 ± 0.07 0.7 ± 0.07
  Normoxia 0.6 ± 0.04 0.7 ± 0.07 0.6 ± 0.04
  Normoxia 0.6 ± 0.04 0.6 ± 0.1 0.6 ± 0.06
  Hypoxic hearts Normoxia 0.8 ± 0.04 0.8 ± 00.07 0.8 ± 0.04
  Early hypoxia 0.4 ± 0.06 0.4 ± 0.06 0.4 ± 0.05
  Late hypoxia 0.2 ± 0.03 0.2 ± 0.06 0.2 ± 0.03
SCR Normoxic hearts Normoxia 0.2 ± 0.03* 0.2 ± 0.04* 0.2 ± 0.03*
  Normoxia 0.3 ± 0.04* 0.2 ± 0.04* 0.3 ± 0.05*
  Normoxia 0.3 ± 0.03* 0.3 ± 0.05* 0.4 ± 0.04*
  Hypoxic hearts Normoxia 0.2 ± 0.04* 0.2 ± 0.04* 0.2 ± 0.02*
  Early hypoxia 0.5 ± 0.1 0.5 ± 0.02 0.5 ± 0.06
  Late hypoxia 0.7 ± 0.05* 0.7 ± 0.05* 0.7 ± 0.05*
  1. The effect of GSH supplementation (with NAC) and GSH depletion (with BSO) upon the amplitudes of the fast clearance rate (FCR) and slow clearance rate (SCR) of 64Cu(ATSM) in normoxic and hypoxic hearts. Data represent means ± SD, n = 5 per group, *p < 0.05 vs. FCR.