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Table 1 Effect of GSH concentration on the fast and slow clearance rates of 64 Cu(ATSM)

From: Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM)

Clearance rate Type of heart Injection Untreated BSO NAC
FCR (kd (min−1)) Normoxic hearts Normoxia 1.2 ± 0.2 1.1 ± 0.1 1.3 ± 0.2
Normoxia 1.1 ± 0.2 1.1 ± 0.2 1.4 ± 0.1
Normoxia 1.2 ± 0.1 1.2 ± 0.2 1.4 ± 0.4
  Hypoxic hearts Normoxia 1.2 ± 0.2 1.1 ± 0.2 1.2 ± 0.2
Early hypoxia 1.9 ± 0.4 1.8 ± 0.5 1.9 ± 0.3
Late hypoxia 2.5 ± 0.6* 2.2 ± 0.5* 2.2 ± 0.8*
SCR (kb (min−1)) Normoxic hearts Normoxia 0.01. ± 0.002 0.008 ± 0.002 0.01 ± 0.006
Normoxia 0.01 ± 0.002 0.01 ± 0.008 0.01 ± 0.006
Normoxia 0.01 ± 0.002 0.01 ± 0.004 0.01 ± 0.004
  Hypoxic hearts Normoxia 0.01 ± 0.007 0.01 ± 0.002 0.01 ± 0.002
Early hypoxia 0.007 ± 0.005 0.008 ± 0.005 0.009 ± 0.002
Late hypoxia 0.003 ± 0.003* 0.004 ± 0.002* 0.005 ± 0.002*
  1. The effect of GSH supplementation (with NAC) and GSH depletion (with BSO) upon the fast clearance rate (FCR) and slow clearance rate (SCR) of 64Cu(ATSM) in normoxic and hypoxic hearts. Data represent means ± SD, n = 5 per group, *p < 0.05 vs. normoxic equivalent.