In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol

EJNMMI Research

Table 3 Ex vivo biodistribution of [¹⁸F]flutemetamol in the mouse head

	Mean	SD
Brain areas
Brain	0.21	0.05
Forebrain	0.19	0.05
Midbrain	0.24	0.04
Hindbrain	0.29	0.07
Olfactory bulb	0.18	0.03
Cortex	0.14	0.02
Cerebellum	0.19	0.06
Medulla	0.86	0.20
Extracranial tissue
Blood	0.32	0.01
Plasma	0.52	0.02
Erythrocytes	0.12	0.01
Cranial bone	0.83	0.13
Submandibular salivary gland	0.16	0.02
Sublingual gland	0.28	0.03
Harderian gland	0.36	0.05
Eyes	0.93	0.11
Nasal cavity	1.89	0.47

Uptake of [¹⁸F]flutemetamol in the brain and adjacent tissues of C57Bl/6 N mice at 60 min post-injection of the tracer (N = 4). Values are presented as percentage of injected dose per gram of tissue (% ID/g).