Ex vivo binding of [18F]flutemetamol to Aβ deposits in the brain of mouse models of AD. (a) Representative brain sections are shown for transgenic (TG) APP23 (27 months), Tg2576 (22 months) and APPswe-PS1dE9 (19 months) mice and wild-type (WT) control mice. Plaque-to-background ratios were calculated from the intensity profiles derived from the areas enclosed in black boxes (FC column). (b) Frontal cortex (FC) to cerebellum (CB) ratios were calculated for TG (filled symbols) and WT (open symbols) animals at different ages. The red symbols represent the ratios from the individual TG animals presented in (a). mo, age of animal in months.