Quantitation of [18F]flutemetamol binding in the brain of mouse models of AD. (a) Logan distribution volume ratios (DVR) and (b) frontal cortex-to-cerebellum ratios from 18F-radioactivity data measured over 50 to 60 min (FC/CB50-60) were calculated for APP23, Tg2576 and APPswe-PS1dE9 transgenic mice, at different ages. For wild-type (WT) control mice, only imaging data from the last PET evaluation are shown for clarity. Different symbols indicate different individual mice. (c) DVRs and FC/CB50-60. Ratios correlated in APP23 mice but not in Tg2576 and APPswe-PS1dE9 mice (linear regression, r2 = 0.76, p = 0.0049, N = 9 (APP23); r2 = 0.13, p = 0.1046, N = 22 (Tg2576); r2 = 0.03, p = 0.5256, N = 17 (APPswe-PS1dE9)).